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Q: Do I need particular skills
to take the measurement?
A: No. You just have to put a finger probe on the patient. This probe is similar to the one used for pulse oximetry. Bio-Clip Plus and its straight-forward software will guide you through the recording and provide you with the results.
Q: Can I use Bio-Clip Plus
on everyone?
A: Pretty much, yes. The only limitation is that a poor signal may be obtained in persons with poor peripheral perfusion. Persons with very cold hands or Raynaud's syndrome may have a
poor signal, which makes it difficult to analyze. This can be overcome by studying people in a warm room. In people with exceptionally high values of arterial stiffness (such as elderly hypertensive subjects) accurate measurements may be difficult to obtain because the direct and reflect components of the pulse overlap too much. Certain types of dysrhythmia may also affect the accuracy.
Q: How are the results presented?
A: Bio-Clip Plus comes with a PC-software program. The Bio-Clip Plus software, version 1.6, uploads all your measurements from the Bio-Clip Plus into a database on your PC. The Bio-Clip Plus software works with Microsoft XP and Vista operating systems. You can navigate through this database using the Bio-Clip Plus software or Microsoft Access.
Q: What is the reproducibility of
the measurements?
A: Depending upon the exact setting, the subject coefficient of variation of SI is between 5 to 10% and RI between 10 to 15%.
Q: How is Reflection Index (RI) used to measure
endothelial function?
A: The change in RI in response to an endothelium dependent vasodilator can be used to measure endothelial function. The ß2-sympathomimetic agonist salbutamol (albuterol) is one such vasodilator and has the advantage that it may be administered by inhalation. This makes a particularly simple measure of endothelial function and has been used in a number of studies.
Q: How does Stiffness Index (SI) compare with other measurements of large artery stiffness?
A: The most widely used measurement of large artery stiffness is aortic pulse wave velocity (PWV). SI is closely correlated with PWV. SI is influenced by age and blood pressure (the major physiological determinants of PWV) in a similar manner to PWV.
Q: Does the measurment change with blood pressure?
A: SI is influenced by blood
pressure as noted above.
RI varies less with blood
pressure but does vary with
heart rate. In part this is
because reduced reflection
is usually associated with a
tachycardia.
 Dale Fowkes, CEO
Health Freedom Nutrition
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